A new method for evaluating antitussives in cats using an electrode-cannula

Eur J Pharmacol. 1975 Nov;34(1):59-63. doi: 10.1016/0014-2999(75)90225-3.

Abstract

An emplaced laryngo-tracheal electrode-cannula was employed to induce and to measure cough in cats anesthetized with either sodium pentobarbital or Dial--urethane. Carbetapentane citrate, codeine sulfate and dextromethorphan hydrobromide were tested for antitussive action by this method. Relative antitussive potency obtained in order of decreasing effectiveness was dextromethorphan hydrobromide, codeine sulfate and carbetapentane citrate.

MeSH terms

  • Animals
  • Antitussive Agents / pharmacology*
  • Carboxylic Acids / pharmacology
  • Catheterization
  • Cats
  • Codeine / pharmacology
  • Cough / physiopathology*
  • Dextromethorphan / pharmacology
  • Electric Stimulation
  • Electrodes
  • Female
  • Larynx / physiology
  • Male
  • Time Factors
  • Trachea / physiology

Substances

  • Antitussive Agents
  • Carboxylic Acids
  • Dextromethorphan
  • Codeine