An unusual sesquiterpene derivative from Ferula kuhistanica

J Nat Prod. 2002 Sep;65(9):1323-4. doi: 10.1021/np020020+.

Abstract

An unusual new sesquiterpene derivative, kuhistaferone (1), was isolated from the fruits of the Uzbekistan medicinal plant Ferula kuhistanica. The structure of 1 was established on the basis of spectroscopic evidence. Compound 1 showed moderate cytotoxicity against the human colon tumor cell line HCT116.

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Colonic Neoplasms
  • Drug Screening Assays, Antitumor
  • Ferula / chemistry*
  • Fruit / chemistry
  • Humans
  • Inhibitory Concentration 50
  • Methicillin / pharmacology
  • Molecular Conformation
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Plants, Medicinal / chemistry*
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology
  • Staphylococcus aureus / drug effects
  • Tumor Cells, Cultured / drug effects
  • Uzbekistan

Substances

  • Anti-Bacterial Agents
  • Antineoplastic Agents, Phytogenic
  • Sesquiterpenes
  • kuhistaferone
  • Methicillin