Abstract
An unusual new sesquiterpene derivative, kuhistaferone (1), was isolated from the fruits of the Uzbekistan medicinal plant Ferula kuhistanica. The structure of 1 was established on the basis of spectroscopic evidence. Compound 1 showed moderate cytotoxicity against the human colon tumor cell line HCT116.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Colonic Neoplasms
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Drug Screening Assays, Antitumor
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Ferula / chemistry*
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Fruit / chemistry
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Humans
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Inhibitory Concentration 50
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Methicillin / pharmacology
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Molecular Conformation
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plants, Medicinal / chemistry*
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Sesquiterpenes / chemistry*
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Sesquiterpenes / isolation & purification*
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Sesquiterpenes / pharmacology
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Staphylococcus aureus / drug effects
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Tumor Cells, Cultured / drug effects
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Uzbekistan
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents, Phytogenic
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Sesquiterpenes
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kuhistaferone
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Methicillin