Klinefelter's syndrome and precocious puberty: a harbinger for tumor

Urology. 2002 Sep;60(3):514. doi: 10.1016/s0090-4295(02)01836-8.

Abstract

Boys with Klinefelter's syndrome are at an increased risk of precocious puberty. Most cases are either idiopathic or due to a mediastinal tumor. Patients with Klinefelter's syndrome are at a high risk of primary, extragonadal germ cell tumors, which are usually nonseminomatous, but can be a mixed type with seminomatous elements. The differential diagnosis of precocious puberty includes mediastinal tumors, especially in boys with Klinefelter's syndrome.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Comorbidity
  • Diagnosis, Differential
  • Epidermal Cyst / diagnosis
  • Epidermal Cyst / epidemiology
  • Germinoma / diagnosis*
  • Germinoma / epidemiology
  • Humans
  • Klinefelter Syndrome / diagnosis*
  • Klinefelter Syndrome / epidemiology
  • Male
  • Mediastinal Neoplasms / diagnosis*
  • Mediastinal Neoplasms / epidemiology
  • Puberty, Precocious / diagnosis*
  • Puberty, Precocious / epidemiology
  • Testicular Neoplasms / diagnosis
  • Testicular Neoplasms / epidemiology