Abstract
Boys with Klinefelter's syndrome are at an increased risk of precocious puberty. Most cases are either idiopathic or due to a mediastinal tumor. Patients with Klinefelter's syndrome are at a high risk of primary, extragonadal germ cell tumors, which are usually nonseminomatous, but can be a mixed type with seminomatous elements. The differential diagnosis of precocious puberty includes mediastinal tumors, especially in boys with Klinefelter's syndrome.
MeSH terms
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Child
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Comorbidity
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Diagnosis, Differential
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Epidermal Cyst / diagnosis
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Epidermal Cyst / epidemiology
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Germinoma / diagnosis*
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Germinoma / epidemiology
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Humans
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Klinefelter Syndrome / diagnosis*
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Klinefelter Syndrome / epidemiology
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Male
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Mediastinal Neoplasms / diagnosis*
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Mediastinal Neoplasms / epidemiology
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Puberty, Precocious / diagnosis*
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Puberty, Precocious / epidemiology
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Testicular Neoplasms / diagnosis
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Testicular Neoplasms / epidemiology