Expression of the LIM-homeodomain gene Lmx1a (dreher) during development of the mouse nervous system

Mech Dev. 2002 Oct;118(1-2):225-8. doi: 10.1016/s0925-4773(02)00254-x.


The expression pattern of Lmx1a, a LIM-homeodomain gene disrupted in the dreher mouse neurological mutant, is described during development. Lmx1a is predominantly expressed in the developing nervous system from embryonic day E8.5 to adulthood, in restricted areas. Major expression domains include the dorsal midline (roof plate) of the neural tube, the cortical hem, the otic vesicles, the developing cerebellum and the notochord. The Lmx1a expression pattern is therefore well correlated with the various aspects of the phenotype of the dreher mutant mice.

MeSH terms

  • Animals
  • Brain / embryology
  • Cloning, Molecular
  • DNA, Complementary / metabolism
  • Homeodomain Proteins / biosynthesis*
  • In Situ Hybridization
  • LIM-Homeodomain Proteins
  • Mice
  • Nervous System / embryology*
  • Neural Crest / embryology
  • Neurons / metabolism
  • Phenotype
  • Protein Structure, Tertiary
  • Reverse Transcriptase Polymerase Chain Reaction
  • Time Factors
  • Transcription Factors


  • DNA, Complementary
  • Homeodomain Proteins
  • LIM-Homeodomain Proteins
  • Lmx1a protein, mouse
  • Transcription Factors