Current molecular models for NADPH oxidase regulation by Rac GTPase

Blood. 2002 Oct 15;100(8):2692-6. doi: 10.1182/blood-2002-04-1149.


Reactive oxygen species (ROS) have been increasingly recognized as important components of cell signaling in addition to their well-established roles in host defense. The formation of ROS in phagocytic and nonphagocytic cells involves membrane-localized and Rac guanosine triphosphatase (GTPase)-regulated reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase(s). We discuss here the current molecular models for Rac GTPase action in the control of the phagocytic leukocyte NADPH oxidase. As a mechanistically detailed example of Rac GTPase signaling, the NADPH oxidase provides a potential paradigm for signaling by Rho family GTPases in general.

Publication types

  • Review

MeSH terms

  • Animals
  • Homeostasis / physiology
  • Humans
  • Models, Molecular
  • NADPH Oxidases / chemistry
  • NADPH Oxidases / genetics
  • NADPH Oxidases / metabolism*
  • Phagocytes / enzymology
  • rac GTP-Binding Proteins / chemistry
  • rac GTP-Binding Proteins / metabolism*


  • NADPH Oxidases
  • rac GTP-Binding Proteins