Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 277 (49), 47517-23

Interleukins 19, 20, and 24 Signal Through Two Distinct Receptor Complexes. Differences in Receptor-Ligand Interactions Mediate Unique Biological Functions

Affiliations

Interleukins 19, 20, and 24 Signal Through Two Distinct Receptor Complexes. Differences in Receptor-Ligand Interactions Mediate Unique Biological Functions

Julia Parrish-Novak et al. J Biol Chem.

Abstract

Cytokines that signal through Class II receptors form a distinct family that includes the interferons and interleukin 10 (IL-10). Recent identification of several IL-10 homologs has defined a cytokine subfamily that includes AK155, IL-19, IL-20, IL-22, and IL-24. Within this subfamily, IL-19, IL-20, and IL-24 exhibit substantial sharing of receptor complexes; all three are capable of signaling through IL-20RA/IL-20RB, and IL-20 and IL-24 both can also use IL-22R/IL-20RB. However, the biological effects of these three cytokines appear quite distinct: immune activity with IL-19, skin biology with IL-20, and tumor apoptosis with IL-24. To more fully elucidate their interactions with the receptor complexes, we have performed a series of in vitro assays. Reporter, proliferation, and direct STAT activation assays using cell lines expressing transfected receptors revealed differences between the receptor complexes. IL-19 and IL-24 also exhibited growth inhibition on a cell line endogenously expressing all three receptor subunits, an effect that was seen at cytokine levels two orders of magnitude above those required for STAT activation or proliferation. These results demonstrate that, although this subclass exhibits receptor complex redundancy, there are differences in ligand/receptor interactions and in signal transduction that may lead to specificity and a distinct biology for each cytokine.

Similar articles

See all similar articles

Cited by 79 PubMed Central articles

See all "Cited by" articles

MeSH terms

LinkOut - more resources

Feedback