Intracameral amphotericin B injection in the management of deep keratomycosis

Cornea. 2002 Oct;21(7):653-6. doi: 10.1097/00003226-200210000-00004.


Purpose: To report the use of intracameral amphotericin B in the management of deep keratomycosis.

Methods: Four patients with deep keratomycosis unresponsive to conventional medical treatment underwent repeated intracameral injections of 5 microg amphotericin B in 0.1 mL 5% dextrose through a paracentesis. Three to 13 intracameral injections were given to each patient over 6 to 36 days.

Results: Three of the four patients had complete resolution of the ulcer. The fourth patient perforated and required evisceration.

Conclusion: Preliminary experience suggests that intracameral injections of amphotericin B may have a role in the management of deep keratomycosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amphotericin B / administration & dosage*
  • Amphotericin B / therapeutic use
  • Antifungal Agents / administration & dosage*
  • Antifungal Agents / therapeutic use
  • Corneal Ulcer / drug therapy*
  • Corneal Ulcer / microbiology*
  • Corneal Ulcer / surgery
  • Eye
  • Eye Evisceration
  • Eye Infections, Fungal / drug therapy*
  • Female
  • Humans
  • Injections
  • Male
  • Middle Aged
  • Retreatment
  • Treatment Outcome


  • Antifungal Agents
  • Amphotericin B