Pregnancy in a patient with primary sclerosing cholangitis

J Clin Gastroenterol. 2002 Oct;35(4):353-5. doi: 10.1097/00004836-200210000-00014.


Primary sclerosing cholangitis (PSC) is a chronic cholestatic syndrome that is characterized by fibrosing inflammatory destruction of intra- and/or extrahepatic biliary ducts. The etiology is unknown and there is no known effective treatment. The course of PSC is quite variable; however, the disease is typically slowly progressive. There is little known regarding the natural history and potential complications of pregnancy in a patient with PSC. This case report details a 36-year-old woman with PSC who became pregnant. The pregnancy was complicated by the development of dominant stricture. A healthy baby boy was delivered at 33.5 weeks. The mother required cholangiography and stent placement immediately after delivery, but her postpartum course was otherwise unremarkable.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Cholangiography*
  • Cholangitis, Sclerosing / diagnostic imaging*
  • Female
  • Humans
  • Infant, Newborn
  • Male
  • Pregnancy
  • Pregnancy Complications / diagnostic imaging*
  • Pregnancy Outcome*