The role of caveolin-1 in androgen insensitive prostate cancer

J Urol. 2002 Oct;168(4 Pt 1):1589-96. doi: 10.1097/01.ju.0000030164.80605.b9.

Abstract

Purpose: We summarize the literature regarding androgen insensitive prostate cancer and caveolin-1. Caveolin-1 is a major structural component of caveolae, membrane micro-domains known to have important roles in signal transduction and lipid transport.

Materials and methods: A review of the literature relevant to androgen insensitive caveolin-1 and prostate cancer included the first published report in 1998 through those published in March 2002.

Results: Caveolin-1 expression is increased in primary and metastatic human prostate cancer with highest levels observed after androgen ablation therapy. Recent studies have documented that caveolin-1 is secreted by prostate cancer cells and can be detected in the serum of men with prostate cancer.

Conclusions: The results presented in this review establish that caveolin-1 is an autocrine/paracrine factor associated with androgen insensitive prostate cancer. They show the potential for caveolin-1 as a biomarker therapeutic target for this important malignancy.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor / physiology
  • Caveolin 1
  • Caveolins / physiology*
  • Humans
  • Male
  • Neoplasm Metastasis / physiopathology
  • Prostatic Neoplasms / pathology*

Substances

  • Biomarkers, Tumor
  • CAV1 protein, human
  • Caveolin 1
  • Caveolins