The association of viral infection and chronic allograft nephropathy with graft dysfunction after renal transplantation

Transplantation. 2002 Aug 27;74(4):576-8. doi: 10.1097/00007890-200208270-00026.


Background: The long-term effect of viral infections on graft dysfunction and rejection after renal transplantation is uncertain.

Methods: A cohort of 37 renal transplant recipients was followed prospectively for 3 years. Creatinine clearance rate at 6 months and 3 years and chronic allograft nephropathy were correlated with the detection of cytomegalovirus (CMV), human herpesvirus 6 and human herpesvirus 7 and BK virus DNA, CMV disease, and acute rejection.

Results: CMV disease was significantly associated with poor graft function at 6 months, whereas chronic allograft nephropathy was associated with graft dysfunction at 3 years. Both CMV disease and detection of human herpesvirus 6 DNA were associated with chronic allograft nephropathy.

Conclusions: CMV disease was a significant cause of early graft dysfunction, whereas the presence of chronic allograft nephropathy was the main determinant of poor long-term graft function. The role of viral infections in chronic allograft nephropathy deserves further investigation.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • BK Virus / isolation & purification
  • Chronic Disease
  • Cohort Studies
  • Cytomegalovirus Infections / physiopathology*
  • DNA, Viral / analysis
  • Herpesvirus 6, Human / isolation & purification
  • Humans
  • Kidney / physiopathology*
  • Kidney Diseases / physiopathology*
  • Kidney Transplantation / adverse effects*
  • Prospective Studies
  • Transplantation, Homologous


  • DNA, Viral