Clinical manifestations and treatment considerations of herpes simplex virus infection

J Infect Dis. 2002 Oct 15;186 Suppl 1:S71-7. doi: 10.1086/342967.


Herpes simplex viruses (HSV) types 1 and 2 cause infections manifesting as dermatologic, immunologic, and neurologic disorders. Some of the most important manifestations and complications of HSV infection are considered here in a neuroanatomic context. This discussion should aid in understanding the pathogenesis and, in some cases, diagnosis and management of associated HSV-related diseases. The sensory nervous system, rather than skin and mucous membranes, is the primary target of HSV infection. With the intention of extending the benefits of acyclovir, valacyclovir is now being explored in a number of HSV-related conditions. This review extends contemporary thinking about how new antiherpetic drugs might be put to greater therapeutic use in the future.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antiviral Agents / therapeutic use*
  • Autonomic Nervous System Diseases / drug therapy
  • Autonomic Nervous System Diseases / pathology
  • Bell Palsy / drug therapy
  • Bell Palsy / pathology
  • Central Nervous System Diseases / drug therapy*
  • Central Nervous System Diseases / pathology
  • Corneal Diseases / drug therapy
  • Corneal Diseases / pathology
  • Corneal Diseases / virology
  • Herpes Simplex / drug therapy*
  • Herpes Simplex / pathology
  • Herpesvirus 1, Human*
  • Herpesvirus 2, Human*
  • Humans
  • Immunocompetence
  • Peripheral Nervous System Diseases / drug therapy*
  • Peripheral Nervous System Diseases / pathology
  • Stomatitis, Herpetic / drug therapy
  • Stomatitis, Herpetic / pathology
  • Trigeminal Nerve Diseases / drug therapy
  • Trigeminal Nerve Diseases / pathology


  • Antiviral Agents