Dendritic cells, BAFF, and APRIL: innate players in adaptive antibody responses

Immunity. 2002 Sep;17(3):235-8. doi: 10.1016/s1074-7613(02)00398-9.

Abstract

The first antibody produced in bacterial or viral infection results from B cell growth as plasmablasts. Dendritic cell-derived TNF-family ligands APRIL and/or BAFF enhance plasmablast survival and differentiation to plasma cells. Expression of these ligands by dendritic cells is promoted by innate immune signals that can convert subliminal B cell activation to a productive response. While this may be lifesaving in the face of infection, it can predispose to autoantibody production.

Publication types

  • Comment
  • Review

MeSH terms

  • Animals
  • Antibody Formation*
  • B-Cell Activating Factor
  • B-Cell Activation Factor Receptor
  • B-Lymphocytes / immunology
  • Cell Movement
  • Dendritic Cells / immunology*
  • Humans
  • Ligands
  • Lymphocyte Activation
  • Lymphocyte Cooperation
  • Lymphoid Tissue / immunology
  • Membrane Proteins / deficiency
  • Membrane Proteins / physiology*
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Models, Immunological
  • Neuropeptides / physiology*
  • Nuclear Proteins / physiology*
  • Plasma Cells / immunology
  • Receptors, Tumor Necrosis Factor / deficiency
  • Receptors, Tumor Necrosis Factor / physiology
  • Signal Transduction
  • Tumor Necrosis Factor-alpha / deficiency
  • Tumor Necrosis Factor-alpha / physiology*

Substances

  • ANP32B protein, human
  • B-Cell Activating Factor
  • B-Cell Activation Factor Receptor
  • Ligands
  • Membrane Proteins
  • Neuropeptides
  • Nuclear Proteins
  • Receptors, Tumor Necrosis Factor
  • TNFRSF13C protein, human
  • TNFSF13B protein, human
  • Tnfrsf13c protein, mouse
  • Tnfsf13b protein, mouse
  • Tumor Necrosis Factor-alpha