Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses

Immunity. 2002 Sep;17(3):341-52. doi: 10.1016/s1074-7613(02)00389-8.

Abstract

Marginal zone (MZ) and B1 B lymphocytes participate jointly in the early immune response against T-independent (TI) particulate antigens. Here we show that blood-derived neutrophil granulocytes and CD11c(lo) immature dendritic cells (DC) are the primary cells that efficiently capture and transport particulate bacteria to the spleen. In a systemic infection, CD11c(lo) DC, but not neutrophils, provide critical survival signals, which can be inhibited by TACI-Fc, to antigen-specific MZ B cells and promote their differentiation into IgM-secreting plasmablasts. In a local TI response, peritoneal cavity macrophages provide similar support to B1 B-derived Ag-specific blasts. In the absence of soluble TACI ligands, Ag-activated MZ- and B1-derived blasts lack survival signals and undergo apoptosis, resulting in severely impaired antibody responses.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adoptive Transfer
  • Animals
  • Antigen Presentation / immunology*
  • Antigens, T-Independent / immunology*
  • Apoptosis / immunology
  • B-Lymphocyte Subsets / immunology*
  • Bacteria / immunology
  • Blood Cells / immunology
  • CD11c Antigen / analysis
  • Cell Differentiation
  • Cells, Cultured / immunology
  • Chemotaxis, Leukocyte
  • Dendritic Cells / immunology*
  • Immunoglobulin M / biosynthesis
  • Immunoglobulin M / immunology
  • Immunologic Deficiency Syndromes / immunology
  • Lymphocyte Activation / immunology
  • Macrophages, Peritoneal / immunology
  • Membrane Proteins*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic
  • Neutrophils / immunology*
  • Plasma Cells / immunology
  • Receptors, Tumor Necrosis Factor / immunology
  • Spleen / cytology
  • Spleen / immunology*
  • Transmembrane Activator and CAML Interactor Protein

Substances

  • Antigens, T-Independent
  • CD11c Antigen
  • Immunoglobulin M
  • Membrane Proteins
  • Receptors, Tumor Necrosis Factor
  • Tnfrsf13b protein, mouse
  • Transmembrane Activator and CAML Interactor Protein