Stabilization signals: a novel regulatory mechanism in the ubiquitin/proteasome system

FEBS Lett. 2002 Oct 2;529(1):22-6. doi: 10.1016/s0014-5793(02)03252-0.


The turnover of cellular proteins is a highly organized process that involves spatially and temporally regulated degradation by the ubiquitin/proteasome system. It is generally acknowledged that the specificity of the process is determined by constitutive or conditional protein domains, the degradation signals, that target the substrate for proteasomal degradation. In this review, we discuss a new type of regulatory domain: the stabilization signal. A model is proposed according to which protein half-lives are determined by the interplay of counteracting degradation and stabilization signals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cysteine Endopeptidases / metabolism*
  • Multienzyme Complexes / metabolism*
  • Proteasome Endopeptidase Complex
  • Protein Conformation
  • Proteins / chemistry
  • Proteins / metabolism*
  • Repetitive Sequences, Amino Acid
  • Signal Transduction*
  • Ubiquitin / metabolism*


  • Multienzyme Complexes
  • Proteins
  • Ubiquitin
  • Cysteine Endopeptidases
  • Proteasome Endopeptidase Complex