CIN85/CMS family of adaptor molecules

FEBS Lett. 2002 Oct 2;529(1):110-5. doi: 10.1016/s0014-5793(02)03188-5.


CIN85 and CMS belong to a family of ubiquitously expressed adaptor molecules containing three SH3 domains, a proline-rich region and a coiled-coil domain. By binding to numerous proteins they assemble multimeric complexes implicated in cell-specific signals controlling T-cell activation, kidney glomeruli function or apoptosis in neuronal cells. CIN85/CMS also associate with accessory endocytic proteins, components of the actin cytoskeleton as well as other adaptor proteins involved in receptor tyrosine kinase (RTK) signaling. These interactions enable CIN85/CMS to function within a network of signaling pathways that co-ordinate critical steps involved in downregulation and degradation of RTKs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Animals
  • Carrier Proteins / chemistry*
  • Carrier Proteins / metabolism*
  • Cytoskeletal Proteins*
  • Endocytosis
  • Humans
  • Kidney / physiology
  • Proteins / chemistry
  • Proteins / immunology
  • Proteins / metabolism
  • Receptor Protein-Tyrosine Kinases / metabolism


  • Adaptor Proteins, Signal Transducing
  • CD2-associated protein
  • Carrier Proteins
  • Cytoskeletal Proteins
  • Proteins
  • SH3KBP1 protein, human
  • Receptor Protein-Tyrosine Kinases