Antimycobacterial anthraquinone-chromanone compound and diketopiperazine alkaloid from the fungus Chaetomium globosum KMITL-N0802

Somdej Kanokmedhakul; Kwanjai Kanokmedhakul; Nutchanat Phonkerd; Kasem Soytong; Palangpon Kongsaeree; Apichart Suksamrarn

doi:10.1055/s-2002-34415

Antimycobacterial anthraquinone-chromanone compound and diketopiperazine alkaloid from the fungus Chaetomium globosum KMITL-N0802

Planta Med. 2002 Sep;68(9):834-6. doi: 10.1055/s-2002-34415.

Authors

Somdej Kanokmedhakul¹, Kwanjai Kanokmedhakul, Nutchanat Phonkerd, Kasem Soytong, Palangpon Kongsaeree, Apichart Suksamrarn

Affiliation

¹ Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand. somdej@kku.ac.th

PMID: 12357398
DOI: 10.1055/s-2002-34415

Abstract

Investigation of the fungus Chaetomium globosum KMITL-N0802 led to the isolation of a novel anthraquinone-chromanone compound named chaetomanone along with seven known compounds, ergosterol, ergosteryl palmitate, chrysophanol, chaetoglobosin C, alternariol monomethyl ether, echinuline and isochaetoglobosin D. These compounds were characterized by spectroscopic methods. Chaetomanone and echinulin exhibited activity towards Mycobacterium tuberculosis.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification
Alkaloids / pharmacology
Anthraquinones / chemistry
Anthraquinones / isolation & purification
Anthraquinones / pharmacology*
Antitubercular Agents / chemistry
Antitubercular Agents / isolation & purification
Antitubercular Agents / pharmacology*
Chaetomium*
Chromones / chemistry
Chromones / isolation & purification
Chromones / pharmacology*
Magnetic Resonance Spectroscopy
Molecular Structure
Mycobacterium tuberculosis / drug effects*

Substances

Alkaloids
Anthraquinones
Antitubercular Agents
Chromones
chaetomanone