Comparison of serum concentrations of soluble adhesion molecules in diabetic microangiopathy and macroangiopathy

Diabet Med. 2002 Oct;19(10):822-6. doi: 10.1046/j.1464-5491.2002.00799.x.

Abstract

Aims: To clarify the correlation between serum concentrations of soluble adhesion molecules and diabetic microangiopathy or macroangiopathy in patients with Type 2 diabetes.

Methods: Patients with diabetic retinopathy and intima-media thickness of common carotid artery (CCA-IMT) < 1.1 mm were classified as the microangiopathy group (n = 62). Patients with CCA-IMT > or = 1.1 mm and without retinopathy were classified as the macroangiopathy group (n = 95). Patients with CCA-IMT < 0.9 mm and without retinopathy were assigned to the no complications group (n = 139). Clinical characteristics and soluble intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin levels were compared between the groups.

Results: Patients with microangiopathy had a significantly longer duration of diabetes, were hypertensive and more likely to have a positive family history of diabetes than the control group. Patients with macroangiopathy were more likely to be smokers, hypertensive, and have a family history of hypertension. Soluble ICAM-1, VCAM-1, and E-selectin levels were significantly higher in the microangiopathy group than in the control group. Soluble VCAM-1 and E-selectin levels, but not ICAM-1 levels, were significantly elevated in the macroangiopathy group. These results were unchanged after adjustment for age, sex, duration of diabetes, blood pressure, HbA1c, HDL-cholesterol, and smoking status.

Conclusions: Our results suggest that soluble adhesion molecules are related to both diabetic micro- and macroangiopathy. The relative contributions of adhesion molecules may be greater in the former than latter patients with Type 2 diabetes.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Analysis of Variance
  • Carotid Artery, Common
  • Cell Adhesion Molecules / blood*
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Diabetes Mellitus, Type 2 / blood*
  • Diabetes Mellitus, Type 2 / diagnostic imaging
  • Diabetic Angiopathies / blood*
  • Diabetic Angiopathies / diagnostic imaging
  • Diabetic Retinopathy / blood
  • Diabetic Retinopathy / diagnostic imaging
  • Female
  • Fluorescein Angiography
  • Glycated Hemoglobin A / analysis
  • Humans
  • Intercellular Adhesion Molecule-1 / blood
  • Male
  • Middle Aged
  • Triglycerides / blood
  • Tunica Intima / diagnostic imaging
  • Ultrasonography
  • Vascular Cell Adhesion Molecule-1 / blood

Substances

  • Cell Adhesion Molecules
  • Cholesterol, HDL
  • Glycated Hemoglobin A
  • Triglycerides
  • Vascular Cell Adhesion Molecule-1
  • Intercellular Adhesion Molecule-1
  • Cholesterol