Primary effusion lymphoma with subsequent development of a small bowel mass in an HIV-seropositive patient: a case report and literature review

Am J Surg Pathol. 2002 Oct;26(10):1363-7. doi: 10.1097/00000478-200210000-00014.


Primary effusion lymphoma is a distinct clinicopathologic entity usually characterized by presentation as a lymphomatous body cavity effusion in the absence of a solid tumor mass or dissemination during its clinical course. This lymphoma is typically present in human immunodeficiency virus (HIV)-infected patients and frequently associated with Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV8) viral sequences. Here we report a rare case of KSHV/HHV8-associated primary effusion lymphoma with secondary involvement of the small bowel as an obstructive tumor mass in an HIV-infected man. The solid small bowel lymphoma demonstrated essentially identical morphology, immunophenotype, KSHV/HHV8 viral status, and immunoglobulin light chain rearrangements to the pleural cavity-based primary effusion lymphoma in the same patient.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • HIV Seropositivity
  • Herpesvirus 8, Human*
  • Humans
  • Immunophenotyping
  • Intestinal Neoplasms / complications
  • Intestinal Neoplasms / pathology*
  • Intestine, Small / pathology*
  • Lymphoma, AIDS-Related / complications
  • Lymphoma, AIDS-Related / pathology*
  • Male
  • Pleural Effusion, Malignant / complications*
  • Pleural Effusion, Malignant / pathology
  • Sarcoma, Kaposi / complications
  • Sarcoma, Kaposi / pathology*