Anti-inflammatory lipid mediators and insights into the resolution of inflammation

Nat Rev Immunol. 2002 Oct;2(10):787-95. doi: 10.1038/nri915.


The pro-inflammatory signalling pathways and cellular mechanisms that initiate the inflammatory response have become increasingly well characterized. However, little is known about the mediators and mechanisms that switch off inflammation. Recent data indicate that the resolution of inflammation is an active process controlled by endogenous mediators that suppress pro-inflammatory gene expression and cell trafficking, as well as induce inflammatory-cell apoptosis and phagocytosis, which are crucial determinants of successful resolution. This review focuses on this emerging area of inflammation research and describes the mediators and mechanisms that are currently stealing the headlines.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / immunology
  • Apoptosis
  • Humans
  • Inflammation / drug therapy
  • Inflammation / etiology*
  • Inflammation / immunology
  • Inflammation / physiopathology
  • Inflammation Mediators / immunology
  • Lipids / immunology*
  • Models, Immunological
  • NF-kappa B / immunology
  • Phagocytosis
  • Signal Transduction


  • Anti-Inflammatory Agents
  • Inflammation Mediators
  • Lipids
  • NF-kappa B