Toll-like receptors as potential therapeutic targets for multiple diseases

Nat Rev Drug Discov. 2002 Oct;1(10):797-807. doi: 10.1038/nrd914.

Abstract

The family of Toll-like receptors (TLRs) is receiving considerable attention as potential regulators and controllers of the immune response through their ability to recognize pathogen-associated molecular patterns. The discovery that endogenous ligands, as well as microbial components, are recognized by TLRs, and that small-molecular-mass synthetic compounds activate TLRs, raised interest in these receptors as potential targets for the development of new therapies for multiple diseases. In this review, we discuss the current and future use of TLR agonists or antagonists in chronic inflammatory diseases and highlight potential problems that are associated with such approaches.

Publication types

  • Review

MeSH terms

  • Animals
  • Drosophila Proteins*
  • Drug Delivery Systems / methods*
  • Humans
  • Inflammation / drug therapy*
  • Inflammation / immunology
  • Inflammation / metabolism
  • Membrane Glycoproteins / agonists*
  • Membrane Glycoproteins / antagonists & inhibitors*
  • Membrane Glycoproteins / physiology
  • Receptors, Cell Surface / agonists*
  • Receptors, Cell Surface / antagonists & inhibitors*
  • Receptors, Cell Surface / physiology
  • Toll-Like Receptors

Substances

  • Drosophila Proteins
  • Membrane Glycoproteins
  • Receptors, Cell Surface
  • Toll-Like Receptors