Clinical translation of angiogenesis inhibitors

Nat Rev Cancer. 2002 Oct;2(10):727-39. doi: 10.1038/nrc905.


Angiogenesis inhibitors are a new class of drugs, for which the general rules involving conventional chemotherapy might not apply. The successful translation of angiogenesis inhibitors to clinical application depends partly on the transfer of expertise from scientists who are familiar with the biology of angiogenesis to clinicians. What are the most common questions that clinicians ask as they begin to test angiogenesis inhibitors in cancer clinical trials?

Publication types

  • Review

MeSH terms

  • Angiogenesis Inhibitors / therapeutic use*
  • Cell Movement
  • Clinical Trials as Topic
  • Drug Resistance, Neoplasm
  • Genes, p53 / genetics
  • Humans
  • Interferon-alpha / therapeutic use
  • Neoplasms / drug therapy*
  • Neovascularization, Pathologic
  • Thalidomide / therapeutic use


  • Angiogenesis Inhibitors
  • Interferon-alpha
  • Thalidomide