Transcription Factors as Targets for Cancer Therapy

Nat Rev Cancer. 2002 Oct;2(10):740-9. doi: 10.1038/nrc906.

Abstract

A limited list of transcription factors are overactive in most human cancer cells, which makes them targets for the development of anticancer drugs. That they are the most direct and hopeful targets for treating cancer is proposed, and this is supported by the fact that there are many more human oncogenes in signalling pathways than there are oncogenic transcription factors. But how could specific transcription-factor activity be inhibited?

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use*
  • Apoptosis
  • Cytoplasm / metabolism
  • Cytoskeletal Proteins / metabolism
  • Humans
  • Ligands
  • Models, Biological
  • Mutation
  • NF-kappa B / metabolism
  • Neoplasms / drug therapy*
  • Protein Binding
  • Proto-Oncogene Proteins / metabolism
  • Signal Transduction
  • Trans-Activators / metabolism
  • Transcription Factors*
  • Transcription, Genetic
  • Wnt Proteins
  • Zebrafish Proteins*
  • beta Catenin

Substances

  • Antineoplastic Agents
  • CTNNB1 protein, human
  • Cytoskeletal Proteins
  • Ligands
  • NF-kappa B
  • Proto-Oncogene Proteins
  • Trans-Activators
  • Transcription Factors
  • Wnt Proteins
  • Zebrafish Proteins
  • beta Catenin