c-MYC: More Than Just a Matter of Life and Death

Nat Rev Cancer. 2002 Oct;2(10):764-76. doi: 10.1038/nrc904.

Abstract

Deregulated expression of c-MYC occurs in a broad range of human cancers and is often associated with poor prognosis, indicating a key role for this oncogene in tumour progression. However, as established human tumours often bear multiple genetic lesions, it is difficult to determine whether c-MYC is instrumental in the initiation/progression of the tumour, or indeed whether inactivating c-MYC would lead to tumour regression. Regulatable transgenic mouse models of oncogenesis have shed light on these issues and provide hope for effective cancer therapies.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis
  • Cell Division
  • Cell Transformation, Neoplastic
  • Chromatin / metabolism
  • Dimerization
  • G1 Phase
  • Humans
  • Mice
  • Mice, Transgenic
  • Models, Biological
  • Phenotype
  • Protein Structure, Tertiary
  • Proto-Oncogene Proteins c-myc / chemistry
  • Proto-Oncogene Proteins c-myc / metabolism*
  • Proto-Oncogene Proteins c-myc / physiology*
  • S Phase
  • Transcription Factors / metabolism

Substances

  • Chromatin
  • Proto-Oncogene Proteins c-myc
  • Transcription Factors