An improved method for the preparation of [11C]verapamil

Appl Radiat Isot. 2002 Oct;57(4):505-7. doi: 10.1016/s0969-8043(02)00143-4.

Abstract

This paper describes an improved preparation of [11C]verapamil by reaction of [11C]methyl triflate with desmethylverapamil. The optimal reaction temperature, amount of precursor and reaction time were assessed. With this method [11C]verapamil can be prepared with a reproducible radiochemical yield of 66 +/- 4% (EOB, based on [11C]methyltriflate). Total synthesis time was 60 min. Radiochemical purity was >99% and specific activities varied between 5 and 30TBq/mmol.

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
  • Carbon Radioisotopes* / chemistry
  • Drug Resistance, Neoplasm
  • Humans
  • Mesylates
  • Methods
  • Radiochemistry
  • Temperature
  • Tomography, Emission-Computed
  • Verapamil / analogs & derivatives*
  • Verapamil / chemical synthesis
  • Verapamil / isolation & purification

Substances

  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Carbon Radioisotopes
  • Mesylates
  • methyl triflate
  • Verapamil