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. 2002 Sep;3(3):383-95.
doi: 10.1016/s1534-5807(02)00221-6.

Association Between the Cell Cycle and Neural Crest Delamination Through Specific Regulation of G1/S Transition

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Association Between the Cell Cycle and Neural Crest Delamination Through Specific Regulation of G1/S Transition

Tal Burstyn-Cohen et al. Dev Cell. .

Abstract

Delamination of premigratory neural crest cells from the dorsal neural tube depends both upon environmental signals and cell-intrinsic mechanisms and is a prerequisite for cells to engage in migration. Here we show that avian neural crest cells synchronously emigrate from the neural tube in the S phase of the cell cycle. Furthermore, specific inhibition of the transition from G1 to S both in ovo and in explants blocks delamination, whereas arrest at the S or G2 phases has no immediate effect. Thus, the events taking place during G1 that control the transition from G1 to S are necessary for the epithelial to mesenchymal conversion of crest precursors.

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