Neural and behavioral substrates of mood and mood regulation

Biol Psychiatry. 2002 Sep 15;52(6):478-502. doi: 10.1016/s0006-3223(02)01458-0.


A review of behavioral and neurobiological data on mood and mood regulation as they pertain to an understanding of mood disorders is presented. Four approaches are considered: 1) behavioral and cognitive; 2) neurobiological; 3) computational; and 4) developmental. Within each of these four sections, we summarize the current status of the field and present our vision for the future, including particular challenges and opportunities. We conclude with a series of specific recommendations for National Institute of Mental Health priorities. Recommendations are presented for the behavioral domain, the neural domain, the domain of behavioral-neural interaction, for training, and for dissemination. It is in the domain of behavioral-neural interaction, in particular, that new research is required that brings together traditions that have developed relatively independently. Training interdisciplinary clinical scientists who meaningfully draw upon both behavioral and neuroscientific literatures and methods is critically required for the realization of these goals.

Publication types

  • Review

MeSH terms

  • Affect*
  • Animals
  • Behavior*
  • Brain / physiopathology*
  • Cognition
  • Humans
  • Models, Neurological
  • Models, Psychological
  • Mood Disorders / physiopathology*
  • Mood Disorders / psychology*
  • National Institute of Mental Health (U.S.)
  • Research / trends*
  • United States