Effects of trimetazidine on tissue damage in kidney after hindlimb ischemia-reperfusion

Pharmacol Res. 2002 Oct;46(4):345-9. doi: 10.1016/s104366180200172x.


The objective of this study was to investigate the effects of trimetazidine (TMZ) on tissue damage in kidney after hindlimb ischemia-reperfusion (I/R), by assessing blood biochemical assay and histopathological analysis. Adult male Wistar rats were divided into two groups. TMZ 10 mg kg(-1)day(-1) was administrated twice a day for 10 days to the treatment group (group T, n=10). Sham group was given only 5% gum arabic (group S, n=10). On 11th day of treatment, 8h I/R period was performed on right hindlimb of the rats. At the end of reperfusion period, a 5 ml blood withdrawn from ascending aorta for biochemical assays and their right kidneys were harvested for histopathological examination. Superoxide dismutase, Na(+)-K(+) ATPase, and reduced glutathione levels were significantly increased in group T (P<0.001). On the other hand, myeloperoxidase and malondialdehyde levels were significantly less in group T than group S (P<0.001). Kidneys from the sham-operated group displayed intense leukocytic infiltration in histopathological examination. These overall results strongly suggested that TMZ contributes renal protection from hindlimb I/R injury by decreasing systemic oxidative stress.

MeSH terms

  • Animals
  • Glutathione / blood
  • Hindlimb / blood supply
  • Hindlimb / physiology*
  • Kidney Diseases / drug therapy*
  • Kidney Diseases / etiology
  • Kidney Diseases / pathology
  • Male
  • Malondialdehyde / blood
  • Oxidation-Reduction
  • Peroxidase / blood
  • Rats
  • Rats, Wistar
  • Regional Blood Flow
  • Reperfusion Injury / complications
  • Reperfusion Injury / diagnosis*
  • Reperfusion Injury / pathology
  • Sodium-Potassium-Exchanging ATPase / blood
  • Superoxide Dismutase / blood
  • Trimetazidine / therapeutic use*
  • Vasodilator Agents / therapeutic use*


  • Vasodilator Agents
  • Malondialdehyde
  • Peroxidase
  • Superoxide Dismutase
  • Sodium-Potassium-Exchanging ATPase
  • Glutathione
  • Trimetazidine