Photodynamic therapy: esophagus

Can J Gastroenterol. 2002 Sep;16(9):642-4. doi: 10.1155/2002/918694.


Photodynamic therapy (PDT) is a minimally invasive, organ-preserving therapeutic modality, involving three separate components - light, oxygen and a photosensitizing drug. The principles of PDT are described, and the indications for its use are reviewed. Although a widespread clinical application for PDT has not yet emerged, PDT may establish itself as an endoscopic procedure with few or no side effects in the treatment of Barrett's esophagus (high-grade dysplasia and early carcinoma) and, in selected cases, for the treatment of early squamous cell carcinoma.

Publication types

  • Review

MeSH terms

  • Barrett Esophagus / drug therapy*
  • Carcinoma, Squamous Cell / drug therapy*
  • Esophageal Diseases / drug therapy*
  • Esophageal Neoplasms / drug therapy*
  • Humans
  • Palliative Care
  • Photochemotherapy*
  • Photosensitizing Agents / therapeutic use


  • Photosensitizing Agents