P53 pathways involving G2 checkpoint regulators and the role of their subcellular localisation

J R Coll Surg Edinb. 2002 Aug;47(4):591-8.

Abstract

DNA damage activates checkpoint pathways to produce a G1 or G2 cell cycle arrest and DNA repair. G2 checkpoint integrity prevents inappropriate mitosis of unrepaired DNA. Cell cycle progression is determined by cyclin-dependent kinase (CDK) enzymes in association with specific cyclin proteins, with Cdc2/cyclin B regulating mitosis. The tumour suppressor p53 re-enforces G2 arrest through the CDK inhibitor, p21(WAF1/CIPI). Functional regulation of G2 checkpoint proteins occurs through levels of protein expression, phosphorylation and subcellular localisation

Publication types

  • Review

MeSH terms

  • Apoptosis / genetics*
  • G2 Phase / genetics*
  • Genes, Regulator / genetics*
  • Genes, p53 / genetics*
  • Humans
  • Neoplasms / genetics*
  • Signal Transduction / genetics*