Distinct hyperintense MRI signal changes in the corticospinal tracts of a patient with motor neuron disease

Amyotroph Lateral Scler Other Motor Neuron Disord. 1999 Dec;1(1):41-4. doi: 10.1080/146608299750138777.


Neuroimaging in motor neuron disease (MND) is currently performed to exclude other pathologies, though abnormalities may be seen which are consistent with the diagnosis. We report a patient with rapidly progressive MND exhibiting extensive changes on a variety of contemporary magnetic resonance images, which is most likely to represent severe corticospinal tract degeneration.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyotrophic Lateral Sclerosis / pathology*
  • Amyotrophic Lateral Sclerosis / physiopathology
  • Brain / pathology*
  • Disease Progression
  • Female
  • Humans
  • Magnetic Resonance Imaging*
  • Middle Aged