The effect of celery and parsley juices on pharmacodynamic activity of drugs involving cytochrome P450 in their metabolism

Eur J Drug Metab Pharmacokinet. 2002 Jul-Sep;27(3):153-6. doi: 10.1007/BF03190450.


Celery (Apium graveolens) and parsley (Petroselinum sativum), plants used worldwide in human nutrition, are the natural sources of methoxsalen. In this study we investigated the effect of mice pretreatment with juices of this plants on the hypnotic action of pentobarbital and analgesic action of paracetamol and aminopyrine, the drugs involving cytochrome P450 superfamily in their metabolism. In mice pretreated with celery and parsley juices a prolonged action of pentobarbital with respect to control was observed, statistical significance being attained only with parsley-pretreated animals. Both pretreatments increased and prolonged the analgesic action of aminopyrine and paracetamol, pretreatment with parsley being again more effective. Celery and parsley juices given to animals two hours before their decapitation caused a significant decrease of cytochrome P450 in the liver homogenate as compared to control.

Publication types

  • Comparative Study

MeSH terms

  • Analgesics, Non-Narcotic / metabolism
  • Analgesics, Non-Narcotic / pharmacology
  • Animals
  • Apium* / chemistry
  • Cytochrome P-450 Enzyme Inhibitors*
  • Cytochrome P-450 Enzyme System / metabolism*
  • Drug Synergism
  • Female
  • Hypnotics and Sedatives / metabolism
  • Hypnotics and Sedatives / pharmacology
  • Liver / enzymology
  • Male
  • Mice
  • Petroselinum* / chemistry
  • Phytotherapy / methods
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Plant Roots / metabolism
  • Rhizome / metabolism


  • Analgesics, Non-Narcotic
  • Cytochrome P-450 Enzyme Inhibitors
  • Hypnotics and Sedatives
  • Plant Extracts
  • Cytochrome P-450 Enzyme System