Corneodesmosin DNA polymorphisms in MHC haplotypes and Japanese patients with psoriasis

Tissue Antigens. 2002 Jul;60(1):77-83. doi: 10.1034/j.1399-0039.2002.600110.x.


In order to examine the relationship between corneodesmosin (CDSN) and psoriasis we have determined the presence of CDSN polymorphisms by DNA sequencing in (a) nine B-LCL cell lines of major histocompatibility complex ancestral haplotypes known to be associated with psoriasis vulgaris including 13.1AH, 46.1AH, 46.2 and 57.1AH, and in (b) a group of 267 unrelated individuals comprising Japanese psoriasis patients (n = 101) and Japanese subjects without the disease (n = 166). Three novel CDSN gene sequences were identified. In addition, we have classified the 18 alleles into seven main groups based on phylogeny of non-synonymous substitutions. However, we have found no statistically significant differences between the patients and the unaffected individuals in any of these groups. These findings indicate that CDSN is not a major psoriasis susceptibility gene.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Base Sequence
  • Genetic Linkage / genetics
  • Genetic Predisposition to Disease / epidemiology
  • Genetic Predisposition to Disease / genetics
  • Glycoproteins / genetics*
  • Haplotypes / genetics*
  • Histocompatibility Antigens Class I / genetics*
  • Humans
  • Intercellular Signaling Peptides and Proteins
  • Japan / epidemiology
  • Major Histocompatibility Complex / genetics*
  • Molecular Sequence Data
  • Polymorphism, Genetic / genetics
  • Psoriasis / epidemiology
  • Psoriasis / genetics*


  • CDSN protein, human
  • Glycoproteins
  • Histocompatibility Antigens Class I
  • Intercellular Signaling Peptides and Proteins
  • MHC class I-related chain A

Associated data

  • GENBANK/AF491325
  • GENBANK/AF491326
  • GENBANK/AF491327
  • GENBANK/AF491328
  • GENBANK/AF491329
  • GENBANK/AF491330