New HLA-A*11 allele, A*1112, identified by sequence-based typing

Tissue Antigens. 2002 Jul;60(1):84-7. doi: 10.1034/j.1399-0039.2002.600111.x.

Abstract

In this report, we describe the identification of HLA-A*1112, a novel HLA-A*11 allele found in two Italian families. The new allele was detected during routine HLA typing by a polymerase chain reaction sequence-specific primer and was confirmed by high-resolution sequencing-based typing. The nucleotide sequences of HLA-A*1112 exons 2 and 3 are identical to HLA-A*11011 except for a single nucleotide substitution in codon 90 (GAC-->GCC).

Publication types

  • Case Reports

MeSH terms

  • Alleles*
  • Amino Acid Sequence
  • Amino Acid Substitution / genetics
  • Base Sequence
  • Codon / genetics
  • Exons / genetics
  • Family Health
  • Fanconi Syndrome / diagnosis
  • Fanconi Syndrome / genetics
  • Female
  • Frameshift Mutation
  • Genetic Predisposition to Disease / genetics
  • HLA-A Antigens / genetics*
  • HLA-A11 Antigen
  • Histocompatibility Testing*
  • Humans
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide / genetics
  • Sequence Alignment
  • Sequence Analysis, DNA

Substances

  • Codon
  • HLA-A Antigens
  • HLA-A11 Antigen

Associated data

  • GENBANK/AF439511