Development of nodes of Ranvier

Curr Opin Neurobiol. 2002 Oct;12(5):476-85. doi: 10.1016/s0959-4388(02)00370-7.


The architecture and function of the nodes of Ranvier depend on several specialized cell contacts between the axon and myelinating glial cells. These sites contain highly organized multimolecular complexes of ion channels and cell adhesion molecules, closely connected with the cytoskeleton. Recent findings are beginning to reveal how this organization is achieved during the development of myelinated nerves. The role of membrane proteins involved in axoglial interactions and of associated cytoplasmic molecules is being elucidated, while studies of mutant mice have underlined the importance of glial cells and the specific role of axonal proteins in the organization of axonal domains.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Adhesion Molecules, Neuronal / metabolism
  • Cell Communication / physiology*
  • Humans
  • Mice
  • Peripheral Nerves / growth & development*
  • Peripheral Nerves / physiology
  • Peripheral Nerves / ultrastructure
  • Potassium Channels / physiology
  • Potassium Channels / ultrastructure
  • Ranvier's Nodes / physiology*
  • Ranvier's Nodes / ultrastructure*
  • Sodium Channels / physiology
  • Sodium Channels / ultrastructure


  • Cell Adhesion Molecules, Neuronal
  • Potassium Channels
  • Sodium Channels