YTH: a new domain in nuclear proteins

Trends Biochem Sci. 2002 Oct;27(10):495-7. doi: 10.1016/s0968-0004(02)02189-8.


A novel 100-150-residue domain has been identified in the human splicing factor YT521-B and its Drosophila and yeast homologues. Homology searches show that the domain is typical for the eukaryotes and is particularly abundant in plants. It is predicted to adopt a mixed alpha-helix-beta-sheet fold and to bind to RNA. We propose the name YTH (for YT521-B homology) for the domain.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Humans
  • Molecular Sequence Data
  • Nuclear Proteins / analysis
  • Nuclear Proteins / chemistry*
  • Protein Structure, Secondary
  • Protein Structure, Tertiary
  • RNA Splicing / physiology
  • Saccharomyces cerevisiae / metabolism
  • Sequence Alignment
  • Sequence Homology, Amino Acid


  • Nuclear Proteins