Posttraining intra-basolateral amygdala scopolamine impairs food- and amphetamine-induced conditioned place preferences

Behav Neurosci. 2002 Oct;116(5):922-7. doi: 10.1037//0735-7044.116.5.922.

Abstract

The present study investigated the role of cholinergic muscarinic receptor function within the basolateral amygdala memory in the consolidation of conditioned place preference (CPP) memory. Adult male Long-Evans rats were confined to treatment- or nontreatment-paired compartments for 30 min on 4 alternating days. After training, rats received intrabasolateral amygdala infusions of scopolamine (2.5 microg or 5.0 microg/0.5 microl) or saline. The rats were then given a 20-min test session, and the time spent in each of the compartments was recorded. Immediate posttraining (but not delayed 2 hr) scopolamine (5.0 microg) blocked acquisition of food- and amphetamine-induced CPPs. The findings indicate a time-dependent role for basolateral amygdala muscarinic receptors in memory consolidation underlying CPPs for natural and drug rewards.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amphetamine / antagonists & inhibitors*
  • Amygdala / cytology
  • Amygdala / drug effects*
  • Amygdala / physiology
  • Analysis of Variance
  • Animals
  • Brain Mapping
  • Central Nervous System Stimulants / antagonists & inhibitors
  • Conditioning, Psychological / drug effects*
  • Dose-Response Relationship, Drug
  • Drug Interactions
  • Food Preferences / drug effects*
  • Male
  • Memory / drug effects*
  • Memory / physiology
  • Muscarinic Antagonists / pharmacology
  • Rats
  • Rats, Long-Evans
  • Scopolamine / pharmacology*
  • Time Factors

Substances

  • Central Nervous System Stimulants
  • Muscarinic Antagonists
  • Amphetamine
  • Scopolamine