Synthesis of specific protein phosphatase inhibitors, tautomycin and tautomycetin toward structure-activity relationship study

Curr Med Chem. 2002 Nov;9(22):2033-53. doi: 10.2174/0929867023368818.

Abstract

The recent progress in synthetic and SAR studies of the specific protein phosphatase inhibitors tautomycin and tautomycetin is reviewed. This article covers the total synthesis of tautomycin and synthetic studies of the spiroketal and the anhydride segments and tautomycetin, and SAR studies on PP inhibition and apoptosis-inducing activity of tautomycin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antifungal Agents / chemical synthesis*
  • Antifungal Agents / chemistry
  • Antifungal Agents / pharmacology
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Furans
  • Humans
  • Lipids
  • Phosphoprotein Phosphatases / antagonists & inhibitors*
  • Pyrans*
  • Spiro Compounds*
  • Structure-Activity Relationship

Substances

  • Antifungal Agents
  • Enzyme Inhibitors
  • Furans
  • Lipids
  • Pyrans
  • Spiro Compounds
  • tautomycin
  • tautomycetin
  • Phosphoprotein Phosphatases