Tubulin as an Antiprotozoal Drug Target

Mini Rev Med Chem. 2002 Dec;2(6):519-29. doi: 10.2174/1389557023405648.

Abstract

Since tubulin is a known anticancer and anthelmintic drug target, the investigation of protozoal tubulin could lead to the development of new antiparasitic drugs. This review outlines the current state of knowledge concerning drug-mammalian tubulin interactions, the effects of antimicrotubule agents on parasites and parasite tubulin, and our current hypotheses regarding the development of selective ligands for protozoal tubulin as antiparasitic drug candidates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antiprotozoal Agents / chemistry
  • Antiprotozoal Agents / pharmacology*
  • Drug Design*
  • Eukaryota / drug effects*
  • Eukaryota / metabolism
  • Humans
  • Ligands
  • Models, Molecular
  • Protozoan Proteins / metabolism*
  • Structure-Activity Relationship
  • Tubulin / metabolism*

Substances

  • Antiprotozoal Agents
  • Ligands
  • Protozoan Proteins
  • Tubulin