Polymorphisms in cytokine genes define subpopulations of HIV-1 patients who experienced immune restoration diseases

AIDS. 2002 Oct 18;16(15):2043-7. doi: 10.1097/00002030-200210180-00009.


Objective: To further elucidate the immunopathogenesis of immune restoration diseases (IRD) in HIV patients responding to antiretroviral therapy and determine whether IRD associated with different opportunistic pathogens involve distinct immunopathological mechanisms.

Design: DNA samples from patients with a range of IRD were typed for polymorphic loci in genes encoding immune-mediators.

Methods: PCR-restriction fragment length polymorphism assays were used to type loci in the and genes. Alleles of a microsatellite in the CD30 promoter were determined by capillary electrophoresis.

Results: Only 8% of patients with IRD associated with a herpesvirus infection carried IL12B-3'UTR*2, compared with 42-54% of patients with other or no IRD. Patients with IRD arising from mycobacterial infection rarely carried IL6-174*C (36% versus 61-71%) and never carried TNFA-308*2 (0% versus 23-52%). TNFA-308*2 was carried by 52% of patients who experienced IRD associated with a herpesvirus infection, as several patients with exacerbations of cytomegalovirus retinitis carried this as part of a HLA-A2,B44 haplotype. Polymorphisms in and showed no distinct patterns.

Conclusions: Distinct cytokine-mediated mechanisms contribute to IRD initiated by herpesvirus and mycobacterial infections.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • AIDS-Related Opportunistic Infections / genetics*
  • AIDS-Related Opportunistic Infections / immunology
  • Adult
  • Antiretroviral Therapy, Highly Active
  • Cytokines / genetics*
  • Cytomegalovirus Retinitis / genetics*
  • Cytomegalovirus Retinitis / immunology
  • Encephalomyelitis / genetics
  • Encephalomyelitis / immunology
  • Genetic Predisposition to Disease*
  • HIV Infections / complications
  • HIV-1
  • Humans
  • Immune System
  • Mycobacterium avium-intracellulare Infection / genetics*
  • Mycobacterium avium-intracellulare Infection / immunology
  • Polymorphism, Genetic*


  • Cytokines