Mycobacterium avium complex pulmonary disease in patients with pre-existing lung disease

Clin Chest Med. 2002 Sep;23(3):643-53. doi: 10.1016/s0272-5231(02)00022-9.


Patients with MAC-PD and pre-existing lung disease are a distinct group from the more common and recently recognized group of predominantly middle- to older-aged women without pre-existing lung disease. Those with pre-existing disease are expected to have more sputum positivity and slower conversion of sputum with treatment, and they may require combined medical treatment with surgical resection for optimal results. Attention to bronchial hygiene, avoidance of unnecessary use of macrolides, and treatment of underlying esophageal and lung disease can result in marked symptomatic improvement in many cases. Appropriate consideration must be given to mycobacterial antibiotic treatment, and awareness must be maintained for other processes such as bronchogenic cancer in select groups of high-risk patients.

Publication types

  • Review

MeSH terms

  • Antibiotics, Antitubercular / therapeutic use
  • Chronic Disease
  • Humans
  • Lung Diseases, Interstitial / complications*
  • Lung Diseases, Interstitial / diagnostic imaging
  • Lung Diseases, Interstitial / therapy
  • Lung Diseases, Obstructive / complications*
  • Lung Diseases, Obstructive / diagnostic imaging
  • Lung Diseases, Obstructive / therapy
  • Mycobacterium avium Complex / isolation & purification*
  • Mycobacterium avium-intracellulare Infection / complications*
  • Mycobacterium avium-intracellulare Infection / diagnostic imaging
  • Mycobacterium avium-intracellulare Infection / therapy
  • Sputum / microbiology
  • Tomography, X-Ray Computed
  • Tuberculosis, Pulmonary / complications*
  • Tuberculosis, Pulmonary / diagnostic imaging
  • Tuberculosis, Pulmonary / therapy


  • Antibiotics, Antitubercular