Identification of TOR signaling complexes: more TORC for the cell growth engine

Cell. 2002 Oct 4;111(1):9-12. doi: 10.1016/s0092-8674(02)01009-7.

Abstract

The Target of Rapamycin (TOR) proteins function in signaling pathways that promote protein synthesis and cell growth. In yeast, TOR signaling is regulated by nutrient availability, whereas in metazoan cells TOR activities may be controlled by both nutrients and growth factors. The recent identification of novel TOR-interacting proteins has provided crucial insights into TOR regulation and function.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Cycle Proteins
  • Cell Division
  • Drosophila
  • Fungal Proteins / chemistry*
  • Fungal Proteins / metabolism
  • Humans
  • Models, Biological
  • Phenotype
  • Phosphatidylinositol 3-Kinases / classification
  • Phosphotransferases (Alcohol Group Acceptor) / chemistry*
  • Phosphotransferases (Alcohol Group Acceptor) / metabolism
  • Protein Structure, Tertiary
  • Saccharomyces cerevisiae / metabolism
  • Saccharomyces cerevisiae Proteins*
  • Signal Transduction*
  • Sirolimus / pharmacology

Substances

  • Cell Cycle Proteins
  • Fungal Proteins
  • Saccharomyces cerevisiae Proteins
  • Phosphatidylinositol 3-Kinases
  • Phosphotransferases (Alcohol Group Acceptor)
  • TOR1 protein, S cerevisiae
  • TOR2 protein, S cerevisiae
  • Sirolimus