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, 12 (21), 3105-9

Indoline and Piperazine Containing Derivatives as a Novel Class of Mixed D(2)/D(4) Receptor Antagonists. Part 1: Identification and Structure-Activity Relationships

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Indoline and Piperazine Containing Derivatives as a Novel Class of Mixed D(2)/D(4) Receptor Antagonists. Part 1: Identification and Structure-Activity Relationships

He Zhao et al. Bioorg Med Chem Lett.

Abstract

Optimization of the lead compound 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihydro-indol-1-yl)-ethanone 1 by systematic structure-activity relation (SAR) studies lead to two potent compounds 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2-methy-2,3-dihydro-indol-1-yl)-ethanone 2n and 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2-methy-2,3-dihydro-indol-1-yl)-ethanone 7b. Their related synthesis was also reported.

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