Time course of serum prolactin and sex hormones following successful renal transplantation

Nephron. 2002;92(3):735-7. doi: 10.1159/000064079.


Background: Chronic renal failure is commonly associated with disturbances in hypothalamic-pituitary-gonadal function.

Methods: The gonadotrophins, prolactin and estradiol or testosterone levels were measured immediately before renal transplantation, at discharge from the transplantation unit (19 +/- 8 days after Tx) and 6 months after transplantation in 21 patients, 7 females and 14 males, age range 21-60 years.

Results: The mean prolactin level was high during uremia and decreased rapidly after transplantation, from 441 to 167 mU/l in males and from 1,057 to 521 mU/l in females. Hypergonadotrophism was seen in most uremic patients, with the mean LH and FSH levels of 14.2 and 6.0 U/l in males and 14.7 and 4.0 U/l in females, respectively. A temporary change to hypogonadotrophic hypogonadism took place 2-3 weeks after transplantation and was followed by normalization of the hypothalamic-gonadal function. The levels of circulating sex steroids were suppressed when the patients were discharged from the transplantation unit but returned to the normal range at 6 months.

Conclusions: We conclude that renal transplantation corrects the hyperprolactinemia induced by uremia and is followed by rapid onset of restoration of the hypothalamic-pituitary-gonadal axis.

MeSH terms

  • Adult
  • Estrogens / blood
  • Female
  • Follicle Stimulating Hormone / blood
  • Gonadal Steroid Hormones / blood*
  • Humans
  • Kidney Failure, Chronic / blood*
  • Kidney Failure, Chronic / surgery
  • Kidney Transplantation*
  • Luteinizing Hormone / blood
  • Male
  • Middle Aged
  • Prolactin / blood*
  • Testosterone / blood
  • Time Factors


  • Estrogens
  • Gonadal Steroid Hormones
  • Testosterone
  • Prolactin
  • Luteinizing Hormone
  • Follicle Stimulating Hormone