Modification of morphine-withdrawal syndrome in rats following transauricular electrostimulation: an experimental paradigm for auricular electroacupuncture

Biol Psychiatry. 1975 Oct;10(5):575-80.


The experimental paradigm reported here provides a useful animal model with which to further study the effects of regional electrostimulation and its possible relationship with electrical acupuncture. What similarities there may be between electrical acupuncture and the technique of regional electrocerebral stimulation used for production of electrosleep and electronarcosis in animals and man (Wageneder et al., 1966) remain to be elucidated. Further research studies, both clinical and basic, are clearly needed to answer some of the questions relating to the safety, efficacy, and possible mechanisms by which a technique such as electrical acupuncture may exert its effects.

MeSH terms

  • Acupuncture Therapy*
  • Animals
  • Behavior, Animal / drug effects
  • Disease Models, Animal*
  • Ear*
  • Electric Stimulation
  • Humans
  • Male
  • Morphine Dependence / drug therapy
  • Morphine Dependence / therapy*
  • Motor Activity / drug effects
  • Naloxone / therapeutic use
  • Rats
  • Substance Withdrawal Syndrome / therapy*


  • Naloxone