Diol- and triol-types of phytol induce apoptosis in lymphoid leukemia Molt 4B cells

Int J Mol Med. 2002 Nov;10(5):555-9.


The exposure of human lymphoid leukemia Molt 4B cells to diol- and triol-types of phytol which were synthesized and identified by Mass, and 1H- and 13C-NMR, led to both growth inhibition and induction of programmed cell death (apoptosis). Morphological changes showing apoptotic bodies were observed in the Molt 4B cells treated with diol- and triol-types of phytol. The fragmentations of DNA by the diol- and triol-types of phytol to oligonucleosomal-sized fragments, that is a characteristic of apoptosis, were observed to be both concentration- and time-dependent. These findings suggest that growth inhibition of Molt 4B cells by the diol- and triol-types of phytol results from the induction of apoptosis in the leukemic cells.

MeSH terms

  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Apoptosis / drug effects*
  • DNA Fragmentation / drug effects
  • Humans
  • Leukemia, Lymphoid / drug therapy*
  • Leukemia, Lymphoid / pathology
  • Molecular Structure
  • Phytol / analogs & derivatives*
  • Phytol / chemical synthesis
  • Phytol / chemistry
  • Phytol / pharmacology
  • Tumor Cells, Cultured


  • Antineoplastic Agents
  • Phytol