Effect of negative air ions on computer operation, anxiety and salivary chromogranin A-like immunoreactivity

Int J Psychophysiol. 2002 Oct;46(1):85-9. doi: 10.1016/s0167-8760(02)00067-3.


The effects of negative air ions on computer operation were examined using a biochemical index of the activity of the sympathetic/adrenomedullary system (i.e. salivary chromogranin A-like immunoreactivity (CgA-like IR)) and a self-report questionnaire (State-Trait Anxiety Inventory, Anxiety State--STAI-S). Twelve female students carried out a word processing task for 40 min. The salivary CgA-like IR increased more than three times on the task, but the salivary cortisol did not change. The increase in the CgA-like IR level was attenuated by the exposure to negative air ions during the task. The exposure to the ions during the recovery period following the task was effective for rapidly decreasing the CgA-like IR level that had increased after the task. These effects by negative air ions were also observed using STAI-S. Task performance was slightly but significantly improved by the presence of negative air ions. These results suggest that negative air ions are effective for the reduction of and the prompt recovery from stress caused by computer operation.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Air / analysis*
  • Anxiety / psychology*
  • Chromogranin A
  • Chromogranins / immunology
  • Chromogranins / metabolism*
  • Computers
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Hydrocortisone / metabolism
  • Ions*
  • Psychomotor Performance / physiology*
  • Saliva / metabolism*
  • Stress, Psychological / psychology
  • Surveys and Questionnaires


  • CHGA protein, human
  • Chromogranin A
  • Chromogranins
  • Ions
  • Hydrocortisone