Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Oct;16(12):1567-74.
doi: 10.1096/fj.02-0209com.

Protection of Innate Immunity by C5aR Antagonist in Septic Mice

Affiliations
Free article

Protection of Innate Immunity by C5aR Antagonist in Septic Mice

Markus S Huber-Lang et al. FASEB J. .
Free article

Abstract

Innate immune functions are known to be compromised during sepsis, often with lethal consequences. There is also evidence in rats that sepsis is associated with excessive complement activation and generation of the potent anaphylatoxin C5a. In the presence of a cyclic peptide antagonist (C5aRa) to the C5a receptor (C5aR), the binding of murine 125I-C5a to murine neutrophils was reduced, the in vitro chemotactic responses of mouse neutrophils to mouse C5a were markedly diminished, the acquired defect in hydrogen peroxide (H2O2) production of C5a-exposed neutrophils was reversed, and the lung permeability index (extravascular leakage of albumin) in mice after intrapulmonary deposition of IgG immune complexes was markedly diminished. Mice that developed sepsis after cecal ligation/puncture (CLP) and were treated with C5aRa had greatly improved survival rates. These data suggest that C5aRa interferes with neutrophil responses to C5a, preventing C5a-induced compromise of innate immunity during sepsis, with greatly improved survival rates after CLP.

Similar articles

See all similar articles

Cited by 49 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback