Acute coronary syndrome: biochemical strategies in the troponin era

Chest. 2002 Oct;122(4):1428-35. doi: 10.1378/chest.122.4.1428.


New biomarkers, such as cardiac troponins, have a major role to play for cost-effective management of individuals with acute chest pain and suspected coronary syndrome, and the laboratory is now poised to assume a vital role in assessing damage and determining prognosis. The redefined biochemical criterion proposed to classify acute coronary syndrome patients presenting with ischemic symptoms as patients with myocardial infarction is heavily predicated on an increased troponin concentration in blood. In an era of evidence-based medicine, we can no longer overlook the diagnostic and prognostic benefits provided by the measurement of these highly sensitive and specific proteins.

Publication types

  • Review

MeSH terms

  • Acute Disease
  • Biomarkers / analysis*
  • Critical Care / methods
  • Electrocardiography
  • Emergency Service, Hospital
  • Evidence-Based Medicine
  • Female
  • Humans
  • Male
  • Myocardial Ischemia / blood
  • Myocardial Ischemia / diagnosis*
  • Myocardial Ischemia / therapy
  • Prognosis
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Troponin / analysis
  • Troponin / blood*


  • Biomarkers
  • Troponin