[Behavior of serum IgE and IgA in patients with allergic rhinitis treated with iodine bromide thermal water]

Acta Otorhinolaryngol Ital. 2002 Aug;22(4):215-9.
[Article in Italian]


The aim of this study was to test the effects of the iodine bromide water of the thermal baths of Salsomaggiore on patients suffering from specific nonseasonal rhinitis (Dermatophagoides Farinae and Dermatophagoides Pteronyssinus). The patients, 80 in all, were divided in two groups (group A and group B). All of the patients underwent rhinoscopic examination, anterior rhinomanometry, prick test, rast screening, total IgE assay together with that of the other immunoglobulins (IgA, IgM, IgG), mucociliary clearance evaluation and were asked to evaluate their degree of nasal obstruction, before and after 30 days of treatment. Group A carried out the experiment by applying endonasal Acqua Sal spray seven times a day for 30 days; group B used oily drops for the same time and with the same frequency. At the end of the trial period, the patients in group A showed a 100% improvement in their subjective perception of their symptomatology, in comparison with a 33% improvement in the control group. A characteristic decrease in the IgE and increase in the IgA was observed in the serum of the patients who had been treated with Acqua Sal spray. Iodine bromide water has a general and local anti-inflammatory effect, which is also due to the activation of the corticosurrenal system (with a relative increase in cortisol). The cleansing action of hypertonic water in the nasal cavities must also be cited, as it minimizes contact between the mucosa and allergens.

MeSH terms

  • Adult
  • Aged
  • Balneology / methods*
  • Bromides / therapeutic use*
  • Female
  • Hot Temperature*
  • Humans
  • Immunoglobulin A / blood*
  • Immunoglobulin E / blood*
  • Iodides / therapeutic use*
  • Male
  • Middle Aged
  • Mucociliary Clearance / immunology
  • Rhinitis, Allergic, Perennial / drug therapy*
  • Rhinitis, Allergic, Perennial / immunology*


  • Bromides
  • Immunoglobulin A
  • Iodides
  • Immunoglobulin E
  • iodobromine