Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats

Res Commun Chem Pathol Pharmacol. 1975 Sep;12(1):185-8.


The same dose of cannabinol (CBN) or cannabidiol (CBD) further increased the attenuation of precipitated abstinence signs observed in morphine-dependent rats that also received an acute dose of delta 9-THC. By contrast, rotational behavior (turning), which is observed concomitantly in THC-treated rats during morphine abstinence, was not increased by CBN, but was potentiated by CBD. These data illustrate differences between psychoinactive cannabinoids in their interaction with delta 9-THC that might be relevant to possible clinical use of Cannabis in narcotic detoxification.

MeSH terms

  • Animals
  • Cannabidiol / pharmacology*
  • Cannabis / pharmacology*
  • Depression, Chemical
  • Dronabinol / pharmacology*
  • Drug Synergism
  • Humans
  • Male
  • Morphine Dependence / physiopathology*
  • Rats
  • Stereotyped Behavior / drug effects
  • Substance Withdrawal Syndrome / physiopathology*


  • Cannabidiol
  • Dronabinol